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Extracellular Vesicles

See the smallest EVs with confidence, NanoFCM’s exceptional sensitivity delivers precise data that you can trust.

What defines real clarity in our single-particle analysis?

NanoFCM’s high sensitivity detection resolve EVs population as small as 40 nm giving you more detection that others might missed.

Multi-parameter fluorescence detection enables both surface andinternal biomolecule co-analysis.

EV measurements are standardized through verifiable sizing and counting standards.

Measurements accuracy is orthogonally verified with a high-resolution technique.

Scientifically validated analytics that ensure reproducibility in every data point

Scientifically validated analytics that ensure reproducibility in every data point

Minimal data distortion though calibrated single-particle measurement for true particle size and concentration

Determine EV purity with membrane fluorescence dye or analyze internal protein with fluorescence probe.

3 fluorescence channel enables co-expression analysis of multiple surface protein simultaneously on the same particle to reveal functional subgroups.

Calculate protein copy number or surface density effortlessly with our one-click analysis that integrates single-biomolecule detection with an advanced algorithm.

mRNA-LNP Therapeutics

From drug development to biomanufacturing, meet regulatory requirement with confidence at every stage.

  • From surface ligand to cargo validation, asingle platform for all your LNP analysis
  • Complete size profiling of lipid nanoparticles from 40 to 200 nm
  • Our LNP empty/full ratio and ligand density analytical solution are recognized as quality attributes and paving the way into regulatory standardization
  • Achieve single-momokcule sensitivity with our Single-Photon Counting Module

Formulation Fine Tuning

Unlabelled sizing & concentration measurement

Affects drug biodistribution and cellular uptake.

Empty/Full Ratio

Fine-tune the LNP-to-nucleic acid (NP) ratio and encapsulation step to maximize LNP drug loading.

mRNA encapsulation efficiency or Copy Number

Determine encapsulated mRNA proportion or mRNA loading yield per LNP and its distribution uniformity to optimize drug loading process.

Ligand Incorporation

Determine ligand copy number or density to optimize targeting and delivery effectiveness.

Meet regulatory requirement

The EMA now outlines clear Critical Quality Attribute (CQA) testing requirements for mRNA-LNP vaccine :
LNP size distributionm
RNA encapsulation efficiency
Unencapsulated or fragmented
Empty particle detection

High-impact features for streamlined workflows

1 µL sample volume to analyze
High throughput 18 sample continuous run per load
Automatic clean up for high productivity
software compliance with regulatory FDA 21CFR part11

Multiparametric Analytics

Quantify both mRNA and surface ligand copy number in addition to size and concentration measurement in a single analysis

Stability Studies

Monitoring changes in particle size and encapsulation efficiency over time under various storage conditions.

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