Breakthrough in Liquid Biopsy for Colorectal Cancer Diagnosis

Update: 2018-01-12 21:07:47

 Our team member, Prof. Xiaomei Yan’s Group has published a paper entitled “Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry” on ACS Nano.

 NanoFCM provides accurate sizing of single EVs with an analysis rate up to 10,000 particles per minute, and the resolution is comparable to that of cryo-TEM. When NanoFCM was used to analyze blood samples, a significantly elevated level of CD147+ EVs was identified in colorectal cancer patients compared to healty donors (P<0.001).

 NanoFCM expands the capability of conventional flow cytometry for single-cell analysis to single EVs, and it enables us to create an objective benchmark to insight into heterogeneous EV populations, which is highly desirable to decipher the biology of EVs and promote the development of EV-base liquid biopsy and therapeutics.

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