Author: Nanofcm     Date: March 4, 2021


  1. Dooley K. P, Harrison, R A, et al. “PREPARATION OF THERAPEUTIC EXOSOMES USING MEMBRANE PROTEINS.” U.S. Patent Application No. 16/722,884.
  2. McConnell, Russell E., et al. “Compositions of engineered exosomes and methods of loading luminal exosomes pay-loads.” U.S. Patent Application No. 16/765,116.
  3. 郑磊,张涵,安泰学,司徒博,李博. Caveolin-1蛋白阳性外泌体作为非小细胞肺癌诊断标志物的应用[P]. CN110095604A,2019-08-06.


  1. Vogel R, Savage J, Muzard J, et al. “Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?.” Journal of Extracellular Vesicles 10.3 (2021): e12052.IF=11
  2. Dong L, Zieren, R. C., et al. “Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium.” Journal of Extracellular Vesicles 10.2 (2020): e12044. IF=11
  3. Dooley K, McConnell, R. E. et al. “A Versatile Platform for Generating Engineered Extracellular Vesicles with Defined Therapeutic Properties.” Molecular Therapy (2021).IF=9
  4. Li J. W, Wei P, Guo, et al. “Clinical significance of circulating exosomal PD-L1 and soluble PD-L1 in extranodal NK/T-cell lymphoma, nasal-type.” American journal of cancer research 10.12 (2020): 4498.IF=4.73
  5. Lv, Y., Chen, J., Hu, J., et al. “Nonmuscle Myosin Heavy Chain ⅡA-Mediated Exosome Release via Regulation of the Rho-Associated Kinase 1/Myosin Light Chains/Actin Pathway.” Frontiers in Pharmacology 11 (2020).IF=3.85
  6. Huang Y, Driedonks T A, Cheng L, et al. “Relationships of Alzheimer’s disease and apolipoprotein E genotypes with small RNA and protein cargo of brain tissue extracellular vesicles.” medRxiv (2020).
  7. Caputo F, Vogel R, Savage J, et al. “Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range.” Journal of Colloid and Interface Science 588: 401-417. IF=7.5
  8. Chen A, Tang S, He J, et al. “Small Extracellular Vesicles From Human Adipose-derived Stem Cells: A Potential Promoter of Keeping Fat Graft Survival.” (2020).
  9. Dietze, R., Hammoud, M. K., Gomez-Serrano, et al. “Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer.” THERANOSTICS 11.3: 1377-1395. IF=8.6
  10. Wei P, Wu F, Kang B, et al. “Plasma extracellular vesicles detected by Single Molecule array technology as a liquid biopsy for colorectal cancer.” Journal of extracellular vesicles 9.1 (2020): 1809765. IF=11
  11. Yang, W. J, Zhang, et al. “Heparanase from triple‑negative breast cancer and platelets acts as an enhancer of metastasis.” International Journal of Oncology 57.4 (2020): 890-904. IF=3.57
  12. Chen Z, Liang Q, Zeng H, et al. “Exosomal CA125 as A Promising Biomarker for Ovarian Cancer Diagnosis.” Journal of Cancer 11.21 (2020): 6445. IF=3.56
  13. Zou X, Yuan M, Zhang T,  et al. “Extracellular vesicles containing host restriction factor IFITM3 inhibited Zika virus infection of fetuses in pregnant mice through trans-placenta delivery.” Molecular Therapy (2020).IF=9
  14. Lai N, Yao Y, Yu T, et al. “Increased Interleukin-6 Levels in Neuron-Derived Plasma Small Extracellular Vesicles of Subarachnoid Haemorrhage Patients.” (2020).
  15. Xiea, M., Caib, X., Sub, J., et al. Exosomal CA125 As A Promising Biomarker For Ovarian Cancer Diagnosis
  16. Soekmadji C, Li B, Huang Y, et al. “The future of Extracellular Vesicles as Theranostics–an ISEV meeting report.” (2020): 1809766. Journal of Extracellular Vesicles. IF=11
  17. Liu Q, Tan Y, Qu T, et al. “Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro.” Life Sciences (2020): 117772.IF=3.45
  18. Wei P, Wu F, Kang B, et al. “Plasma extracellular vesicles detected by Single Molecule array technology as a liquid biopsy for colorectal cancer.” Journal of Extracellular Vesicles 9.1 (2020): 1809765.IF=11
  19. Yang W. J., Zhang, G. L., et al. “Heparanase from triple‑negative breast cancer and platelets acts as an enhancer of metastasis.” International Journal of Oncology.IF=3.57
  20. Lv Q, Cheng L, Lu Y, et al. “Thermosensitive Exosome–Liposome Hybrid Nanoparticle‐Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer.” Advanced Science (2020): 2000515. IF=15.8
  21. Cheng C, Zhang Z, Cheng F, et al. “Exosomal lncRNA RAMP2-AS1 Derived from Chondrosarcoma Cells Promotes Angiogenesis Through miR-2355-5p/VEGFR2 Axis.” OncoTargets and therapy 13 (2020): 3291. IF=3.3
  22. Xu J, Su L, Han J, et al. “Rapid and quantitative in vitro analysis of mitochondrial fusion and its interplay with apoptosis.” Talanta (2020): 121523.IF=4.91
  23. Ling H, Guo Z, Shi Y, et al. “Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome.” Frontiers in Physiology 11 (2020).IF=3.4
  24. Zhuang J. L Shen, Y M,  et al. “Electrochemical Deposition of Perylene-based Thin Films from Aqueous Solution and Studies of Visible Light-driven Oxidation of Alcohols.” ACS Applied Energy Materials (2020).
  25. Mallick E R., Arab, Huang al. “Characterization of extracellular vesicles and artificial nanoparticles with four orthogonal single-particle analysis platforms.” BioRxiv (2020).
  26. Jiwei Li,Ping Wei,Ye Guo,et al. “Clinical Significance of Circulating Exosomal PD-L1 and Soluble PD-L1 in Nasal-type NK/T-cell Lymphoma Patients,Receiving VIPD Containing Chemotherapy” Research Square 2020
  27. Xia Y, Ling X, Hu G, et al. “Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke.” Stem Cell Research & Therapy 11.1 (2020): 1- 17.   IF=4.62
  28. Han Z, Li Y, Zhang J,et al. “Tumor-derived circulating exosomal miR-342-5p and miR-574-5p as promising diagnostic biomarkers for early-stage Lung Adenocarcinoma.” Int J Med Sci 17.10 (2020): 1428-1438.
  29. Wang J, Hu R, Xing Q,et al. “Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells Alleviate Mifepristone-Induced Human Endometrial Stromal Cell Injury.” Stem Cells International 2020 (2020).IF=3.9
  30. López E, Marinaro F, de Pedro, et al. “The immunomodulatory signature of extracellular vesicles from Cardiosphere-Derived Cells: a proteomic and miRNA profiling.” Frontiers in Cell and Developmental Biology 8 (2020).IF=5.2
  31. Gandham S, Su X, Wood J, et al. “Technologies and Standardization in Research on Extracellular Vesicles.” Trends in Biotechnology (2020).IF=13.74
  32. Ma K, Zhu B, Wang Z, et al. “Articular chondrocyte derived exosomes promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy.” (2020).
  33. Liu Q, Tan Y, Qu T, et al. “Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro.” Life Sciences (2020): 117772. IF=3.44
  34. Lin W, Xu Y, Chen X, et al. “Radiation-induced small extracellular vesicles as “carriages” promote tumor antigen release and trigger antitumor immunity.” Theranostics 10.11 (2020): 4871. IF=8.06
  35. Chen, Jin, et al. “Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation.” Stem cell research & therapy 11.1 (2020): 1-13.IF=4.62
  36. Zhang X, Song D, Zhou W, et al. “Seminal plasma exosomes evoke calcium signal via CatSper channel to regulate human sperm function.” bioRxiv (2020).
  37. Liang M, Yu S, Tang S , et al. “A Panel of Plasma Exosomal miRNAs as Potential Biomarkers for Differential Diagnosis of Thyroid Nodules.” Frontiers in Genetics 11 (2020): 449.IF=3.51
  38. Brambilla D, Sola L, Chiodi, et al. “Separation of extracellular vesicles by DNA-directed immunocapturing followed by enzymatic release.” (2020).
  39. Ke C, Hou H., Li J et al. Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib. Cancers, 12(5), 1157. (2020) . IF=6.16
  40. C Mao, C Xue, X Wang, et al. “Rapid quantification of pathogenic Salmonella Typhimurium and total bacteria in eggs by nano-flow cytometry.” Talanta (2020): 121020.IF=4.91
  41. Wanzun Lin, Yanyan Xu, Xiaochuan Chen et al. “Radiation-induced small extracellular vesicles as “carriages” promote tumor antigen release and trigger antitumor immunity.” Theranostics 10.11 (2020): 4871. IF=8.06
  42. Yang C, Sun S, Zhang Q, et al. Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway. Stem Cells International, 2020. IF=3.9
  43. Liu M, Qiu Y, Xue Z, et al. “Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway.” Stem Cell Research & Therapy 11.1 (2020): 3.IF=4.62
  44. Hu G, Xia Y, Zhang J, et al. “ESC‐sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.” Advanced Science (2020).IF=15.80
  45. Chen Q, Huang M, Wu J, et al. “Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70.” Aging (Albany NY) 12.4 (2020): 3682.IF=5.51
  46. Zieren R C, Dong L, Pierorazio P M, et al. Extracellular vesicle isolation from human renal cancer tissue. Medical Oncology, 2020, 37(4): 1-11.IF=3.25
  47. Shen Y F, Huang J H, Wang K Y, et al. PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities. Cell Communication and Signaling, 2020, 18(1): 1-15.IF=5.11
  48. Tian L, Yang L, Zheng W, et al. RNA sequencing of exosomes revealed differentially expressed long noncoding RNAs in early-stage esophageal squamous cell carcinoma and benign esophagitis. Epigenomics, 2020 (0).IF=4.4
  49. Chen J, Chen J, Cheng Y, et al. Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation. Stem Cell Research & Therapy, 2020, 11(1): 1-13.IF=4.6
  50. Hu J, Tang T, Zeng Z, et al. The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome. PeerJ, 2020, 8: e8640.IF:=2.3
  51. Mi B, Chen L, Xiong Y, et al. Saliva Exosomes-Derived UBE2O Promotes Angiogenesis in Cutaneous Wounds By Targeting SMAD6. Available at SSRN 3518830.IF=6.6
  52. Jiang W, Ma P, Deng L, et al. Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles. Journal of Extracellular Vesicles, 2020, 9(1): 1716513. IF=11.00
  53. Tian Y, Gong M, Hu Y, et al. Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry. Journal of Extracellular Vesicles, 2020, 9(1): 1697028. IF= 11.00
  54. Ling X, Zhang G, Xia Y, et al. Exosomes from human urine‐derived stem cells enhanced neurogenesis via miR‐26a/HDAC6 axis after ischaemic stroke. Journal of Cellular and Molecular Medicine, 2020. IF=4.7
  55. Kim S Y, Joglekar M V, Hardikar A A, et al. Placenta Stem/Stromal Cell–Derived Extracellular Vesicles for Potential Use in Lung Repair. Proteomics, 2019, 19(17): 1800166. IF=3.1
  56. Zhang Q, Liu R X, Chan K W, et al. Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells. Journal of Experimental & Clinical Cancer Research, 2019, 38(1): 320. IF=5.65
  57. Dong Z, Sun X, Xu J, et al. Serum Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA Protected by Exosomes as a Potential Biomarker for Gastric Cancer. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 2019, 25: 7770. IF=1.98
  58. Yu S, Li Y, and Liao Z et al.Plasma Extracellular Vesicle Long RNA Profiling Identifies a Diagnostic Signature for the Detection of Pancreatic Ductal Adenocarcinoma. Gut, gutjnl-2019-318860. IF: 17.94
  59. Deng C, Xie Y, and Zhang C et al. Urine-Derived Stem Cells Facilitate Endogenous Spermatogenesis Restoration of Busulfan-Induced Nonobstructive Azoospermic Mice by Paracrine Exosomes. Stem Cells and Development, 2019, 28, 1322-1333. IF: 3.73
  60. Bai L, Li J, and Li H et al. Renoprotective Effects of Artemisinin and Hydroxychloroquine Combination Therapy on IgA Nephropathy via Suppressing NF-κB Signaling and NLRP3 Inflammasome Activation by Exosomes in Rats. Biochemical Pharmacology, 2019, 169, 113619. IF:4.82
  61. Zhang Y, Jin X, and Liang J et al. Extracellular Vesicles Derived from ODN-stimulated Macrophages Transfer and Activate Cdc42 in Recipient Cells and Thereby Increase Cellular Permissiveness to EV Uptake. Science Advances, 2019, 5: eaav1564. IF: 12.80
  62. Zhu Q, Ling X, and Deng Z et al. Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy. Advanced Science, 2019, 6, 1801899. IF: 15.80
  63. Lv P, Liu X, and Liu G et al. Genetically Engineered Cell Membrane Nanovesicles for Oncolytic Adenovirus Delivery: A Versatile Platform for Cancer Virotherapy. Nano Letters, 2019, 19, 2993-3001. IF: 12.27
  64. Wany Y, Melvin R, Bemis L, Worrell G, Wang H. Programmable Modulation for Extracellular Vesicles. doi:
  65. Li Y, Zhao J, and Huang S et al. Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis. Clinical Chemistry, 2019 65(6), 798-808. IF: 6.89
  66. Lian H, He S, Chen C, and Yan X. Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles. Annual Review of Analytical Chemistry. 2019. 12:22.1-22.21. IF: 8.72
  67. Chen C, Gao K, and Yan X, et al. Single-Particle Characterization of Theranostic Liposomes with Stimulus Sensing and Controlled Drug Release Properties. Biosensors and Bioelectronics, 2019, 131, 185-192. IF: 8.81
  68. Tian Y, Ma L, Gong M, et al. Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry. ACS Nano, 2018, 12(1), 671-680. IF: 13.71
  69. Dong C, Huang L, Melo S, Kurywchak P, Peng Q, Kahlert C, LeBleu V, and Kalluri R. Multiple antibodies identify glypican-1 associated with exosomes from pancreatic cancer cells and serum from patients with pancreatic cancer. doi:
  70. Xu H, Liao C, Zuo P, Liu Z, and Ye B. Magnetic-Based Microfluidic Device for On-Chip Isolation and Detection of Tumor-Derived Exosomes. Analytical Chemistry, 2018, 90(22), 13451-13458. IF: 6.35
  71. Zhang W, Tian Y, and Yan X et al. Light-Scattering Sizing of Single Submicron Particles by High-Sensitivity Flow Cytometry. Analytical Chemistry, 2018, 90, 12768-12775. IF: 5.86
  72. Yan Y, Meng L, and Yan X et al. High-Throughput Single-Nanoparticle Analysis of Metal-Enhanced Fluorescence in Free Solution Using Ag@SiO2 Core-Shell Nanoparticles. ACS Sensors, 2017, 2, 1369-1376. IF: 6.94
  73. Wang S, Li L, and Yan X et al, Rapid and Quantitative Measurement of Single Quantum Dots in a Sheath Flow Cuvette. Analytical Chemistry, 2017, 89, 9857-9863. IF: 5.86
  74. Chen C, Zhu S, Wang S, Zhang W, Cheng Y, and Yan X. Multiparameter Quantification of Liposomal Nanomedicines at the Single-Particle Level by High-Sensitivity Flow Cytometry. ACS Applied Materials and Interfaces, 2017, 9, 16, 13913-13919. IF: 8.46
  75. Wu L, Wang X, and Yan X et al. Flow Cytometric Single-Cell Analysis Enables Quantitative in vivo Detection of Protein-Protein Interactions via Relative Reporter Protein Expression Measurement. Analytical Chemistry, 2017, 89, 2782-2789. IF: 5.86
  76. He S, Hong X, Huang T, Zhang W, and Yan X et al. Rapid quantification of live/dead lactic acid bacteria in probiotic products using high-sensitivity flow cytometry. Methods and Applications in Fluorescence, 2017(5), 024002. IF: 2.94
  77. Ma L, Zhu S, Tian Y, et al. Label‐Free Analysis of Single Viruses with a Resolution Comparable to That of Electron Microscopy and the Throughput of Flow Cytometry. Angewandte Chemie, 2016, 55(35):10239-10243. IF: 11.18
  78. Huang T , Zheng Y , Yan Y , et al. Probing minority population of antibiotic-resistant bacteria. Biosensors and Bioelectronics, 2016, 80:323-330. IF: 8.83
  79. Zhu S, Ma L, Wang S, et al. Light-Scattering Detection below the Level of Single Fluorescent Molecules for High-Resolution Characterization of Functional Nanoparticles. ACS Nano, 2014, 8(10):10998-11006. IF: 13.71
  80. Zhang X, Zhang S, and Yan X et al. Identification of Mitochondria-Targeting Anticancer Compounds by an in Vitro Strategy. Analytical Chemistry, 2014, 86, 5232-5237. IF: 5.86
  81. Chen C, Zhang X, Zhang S, et al. Quantification of protein copy number in single mitochondria: The Bcl-2 family proteins. Biosensors & Bioelectronics, 2015, 74:476-482. IF: 8.83
  82. Yang L, Huang T, and Yan X et al. High-throughput single-cell analysis of low copy number beta-galactosidase by a laboratory-built high-sensitivity flow cytometer. Biosensors & Bioelectronics, 2013, 48, 49-55. IF: 8.83
  83. Chen C, Zhu S, and Yan X et al. Analytical techniques for single-liposome characterization. Analytical Methods, 2013, 5, 2150-2157. IF: 2.38
  84. Wu L, Luan T, and Yan X et al. Trace Detection of Specific Viable Bacteria by Using Tetracysteine-Tagged Bacteriophages. Analytical Chemistry, 2014, 86(1), 907-912. IF: 5.86
  85. Zhang S, Zhu S, and Yan X et al. High-Throughput Multiparameter Analysis of Individual Mitochondria. Analytical Chemistry, 2012, 84, 6421-6428. IF: 5.86
  86. Yang L, Zhou Y, and Yan X et al. Detection and Quantification of Bacterial Autofluorescence at the Single-Cell Level by a Laboratory-Built High-Sensitivity Flow Cytometer. Analytical Chemistry, 2012, 84, 1526-1532. IF: 5.86
  87. Zhu S, Wang S, and Yan X et al. Progress in the development of techniques based on light scattering for single nanoparticle detection. Science China Chemistry, 2011, 54(8), 1244-1253. IF: 6.08
  88. Wu L, Huang T, and Yan X et al. Sensitive and Selective Bacterial Detection Using Tetracysteine-Tagged Phages in Conjunction with Biarsenical Dye. Angewandte Chemie International Edition, 2011, 50, 5873-5877. IF: 11.18
  89. Zhu S, Yang L, and Yan X et al. Size Differentiation and Absolute Quantification of Gold Nanoparticles via Single Particle Detection with a Laboratory-Built High-Sensitivity Flow Cytometer. Journal of American Chemical Society, 2010, 132, 12176-12178. IF: 13.67
  90. Yang L, Wu L, and Yan X et al. Rapid, Absolute, and Simultaneous Quantification of Specific Pathogenic Strain and Total Bacterial Cells Using and Ultrasensitive Dual-Color Flow Cytometer. Analytical Chemistry, 2010, 82, 1109-1116. IF: 5.86
  91. Yang L, Zhu S, and Yan X et al. Development of an Ultrasensitive Dual-Channel Flow Cytometer for the Individual Analysis of Nanosized Particles and Biomolecules. Analytical Chemistry, 2009, 81, 2555-2563. IF: 5.86